Evidence ledger
Paracelsus codifies published medicine — it does not invent theory. This ledger lists every calculator and work-up, the sources it is built from, and when its codification was last reviewed against them. A release fails automatically if anything here goes missing.
Work-ups
Resuscitation Council UK, ABCDE approach · RCP NEWS2 (2017) · Sepsis-3 (Singer 2016); Surviving Sepsis Campaign 2021 · RCP NEWS2 (2017); SSC 2021 · RCP NEWS2 (2017); Sepsis-3 (2016)
ESC STEMI guideline; local ACS pathway · Six 2008; Backus 2013 · Backus 2013; Poldervaart 2017 · Backus 2013; ESC NSTE-ACS guideline
ESC AF guideline 2020 · ESC AF guideline 2020; Pisters 2010
Wells 2003; CHEST antithrombotic guidelines · Wells et al., NEJM 2003 · Wells 2003
Lim 2003; BTS CAP guideline; NICE CAP · BTS CAP guideline · Lim 2003; BTS CAP guideline · Lim 2003; BTS CAP guideline; SSC 2021
Standard emergency practice; local ENT policy · Centor 1981; McIsaac 1998 · McIsaac 1998; IDSA pharyngitis guideline · McIsaac 1998 (empiric option); IDSA pharyngitis guideline (testing)
Kline et al. 2004; ACEP guidance · Wells 2000; van Belle (Christopher study) 2006 · Wells 2000; ESC 2019 PE guideline · Wells 2000; Christopher study 2006
Growth & measurement
WHO classification of adult BMI
Devine: 50 kg (male) / 45.5 kg (female) + 2.3 kg per inch over 152 cm. Not defined below 152 cm. Reference: Devine 1974
Renal & electrolytes
CKD-EPI 2021 race-free creatinine equation (Inker et al., NEJM). Adults only
Corrected Ca = total Ca + 0.02 × (40 − albumin). Reference: Payne et al., BMJ 1973
AG = Na − (Cl + HCO₃). Reference interval varies by analyser (≈ 4–12 mmol/L) · Corrected AG = AG + 0.25 × (40 − albumin g/L) — low albumin hides a raised gap. Reference: Figge 1998
Hillier et al. 1999 (2.4 factor; the older Katz factor is 1.6)
Fazekas et al., Intensive Care Med 2013 (equation review)
Espinel, JAMA 1976; Carvounis et al., Kidney Int 2002
Scores & indices
Teasdale & Jennett, Lancet 1974
ESC AF guidelines; validation: Lip et al. 2010
Lim et al., Thorax 2003
Wells et al. 2000
Royal College of Physicians, NEWS2 (2017)
Wells et al., NEJM 2003
Kline et al., J Thromb Haemost 2004
Seymour et al., JAMA 2016 (Sepsis-3)
Pisters et al., Chest 2010
Target ≥ 65 mmHg in septic shock; individual targets vary. Reference: Surviving Sepsis Campaign 2021
Bazett 1920; Fridericia 1920
Centor 1981; McIsaac, CMAJ 1998; McIsaac, JAMA 2004 (validation)
Stiell et al. 1992 (derivation), 1993 (validation), 1994 (implementation)
Score each component from the bedside; the troponin band uses your laboratory's reference limit · Six 2008 (derivation); Backus 2013 (validation); Poldervaart 2017 (implementation)
Dosing
CrCl = (140 − age) × weight / (72 × SCr) × 0.85 if female. Reference: Cockcroft & Gault 1976
maintenance adjustment percentages per anticoagulation-clinic protocols (Horton & Bushwick, AFP 1999); high-INR and bleeding management per CHEST 2012 (Holbrook)
Baxter & Shires 1974
Holliday & Segar, Pediatrics 1957
Blood gases & acid-base
Compensation: Winter's (metabolic acidosis), 0.7×ΔHCO₃ (metabolic alkalosis), 1/4–5 per 10 mmHg pCO₂ (respiratory). References: Winter 1967; Berend et al., NEJM 2014
Neonatal & paediatrics
Phototherapy and exchange thresholds are gestation- and hour-specific — plot TSB on your unit's chart. References: AAP 2022; NICE NG98. Chart-based thresholds are coming to this tool
The score does not direct resuscitation — follow NLS/NRP algorithms. Reference: Apgar 1953
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